37571-37581(1)

37571-37581(1) - Introduction to Radiation Health: Late...

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Unformatted text preview: Introduction to Radiation Health: Late Effects - Cancer Dr. Niel Wald Radiobiological Effects • Non-Stochastic – Severity varies with dose – May have threshold (cataract, dermatitis) • Stochastic – Probability of occurrence in population varies with dose – No threshold (cancer, genetic damage) 227-4 Intracellular Effects of Radiation 138-A Classification of Neoplasms Tissue Origin Benign Malignant Examples Epithelial Glandular Adenoma Adenocarcinoma Thyroid follicular adenoma Adenocarcinoma of lung Squamous and Transitional Polyp, papilloma Squamous cell carcinoma Transitional cell carcinoma Squamous papiloma of skin Squam. cell carcinoma skin Connective tissue Tissue type + suffix (-oma) Sarcoma Osteoma, Osteosarcoma, Hemangioma, Hemangiosarcoma Hematopoietic & lymphoreticular Lymphoma Leukemia Large cell lymphoma Hodgkin’s disease Mylocytic leukemia Neural tissue Neuroma Neurofibroma Sarcoma Blastoma Glioblastoma multiforme Neurofibrosarcoma Mixed tissues of origin Teratoma Teratocarcinoma Teratoma of ovary Teratocarcinoma of testis 395-4 Basis for Tumor Dose:Response Estimates 175-3 Tumor Growth Curve 395-6 Scheme for Induction of Cancer by Environmental Carcinogens Chemical or Radiation Carcinogen Initiator(s) (electrophilic, mutagenic) Promoter(s) Inactive Metabolites Normal Cells Initiated Cells Tumor Cells Clones Gross Tumors Courtesy of Miller and Miller 395-11 395-1 395-2 395-3 Three germ layers and the tissues derived from them Embryonic origin Adult derivative Ectoderm Skin Brain Breast Sweat glands etc. Mesoderm Fibrous tissue (connective) Cartilage Bone Muscle etc. Endoderm Gut Liver Lung Pancreas etc. 666-1 Histogenetic classification of benign tumors Normal tissue Resultant Benign tumor Glandular epithelium Surface epithelium Fibroblasts Cartilage Striated Muscle Smooth Muscle Blood Vessels Fat Bone Liver Adenoma Papilloma Fibroma Chondroma Rhabdomyoma Leiomyoma Hemangioma Lipoma Osteoma Hepatoma 642-1 Histogenetic classification of malignant tumors Normal tissue Resultant Malignant tumor Epithelium Connective tissue Bone Marrow Carcinoma Sarcoma Leukemia More Specifically: Glandular epithelium Squamous epithelium Fibroblasts Cartilage Striated Muscle Smooth Muscle Endothelium Fat Bone Liver Adenocarcinoma Squamous carcinoma Fibrosarcoma Chondrosarcoma Rhabdomyosarcoma Leiomyosarcoma Angiosarcoma Liposarcoma Osteosarcoma Hepatocellular carcinoma 642-2(1) Histogenetic Classification of Malignant Tumors with Atypical Nomenclature: Normal tissue Resultant Malignant tumor Skin- melanocytes Fibroblast/histiocyte Myeloid stem cells Plasma cells Lymphoid tissue Sympathetic neurones (neuroblasts) ? Endothelium Embryonal kidney Embryonal retina Gonad (male germ cells) Gonad (female germ cells) Germ cells Malignant melanoma Malignant fibrous histiocytoma Myeloid leukemia Multiple myeloma Lymphoma/Hodgkin’s Dis....
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This note was uploaded on 02/23/2012 for the course SCI 310 taught by Professor Staff during the Fall '10 term at Rutgers.

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37571-37581(1) - Introduction to Radiation Health: Late...

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