42691 - Cancer Epidemiology The need for Global Information...

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Unformatted text preview: Cancer Epidemiology: The need for Global Information sharing in obesity and cancer ? Edinburgh, August 2011 Faina Linkov, PhD Research Assistant Professor University of Pittsburgh What is cancer? Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle. Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. While many diseases (such as heart failure) may have a worse prognosis than most cases of cancer, it is the subject of widespread fear and taboos. Increase in uterine cancer mortality might be associated with increase in obesity epidemic Why is it important to prevent cancer? • Treatment options are not available for several forms of cancer • Existing cancer treatments do not target specific cancer cells • Existing cancer treatments have many undesirable side effects and are not always 100% effective • One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. Obesity and Cancer: Mechanisms Adipose tissue is an active endocrine organ Mechanisms by which adipose tissue may influence cancer risk- Production of sex steroid hormones (e.g., estrogen, Production of sex steroid hormones (e....
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42691 - Cancer Epidemiology The need for Global Information...

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