43581-43591(1)

43581-43591(1) - PREVENTABLE CAUSES OF CANCERS: REVISITING...

Info iconThis preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon
PREVENTABLE CAUSES OF CANCERS: REVISITING THE 1981 DOLL & PETO REPORT Gilbert S. Omenn, M.D.,Ph.D. David Schottenfeld Lecturer, 20 July, 2011 University of Michigan School of Public Health Based on collaboration of David Schottenfeld, Patricia Buffler, Steven Gruber, and Gil Omenn for EPID704, UM Graduate Summer Program in Epidemiology, 26-30 July, 2010
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Honoring Dr. David Schottenfeld
Background image of page 2
3 The Newest, Up-to-Date Volume by David Schottenfeld C a n c e r E p id m io lo g y
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cancer Incidence and Mortality, USA The American Cancer Society estimates 1.53 million new cases and 570,000 deaths from cancers in 2011. Women top 3: breast, lung, colon; overall mortality rate is down 12.3% 1990-2006 Men top 3: prostate, lung, colon; overall mortality rate is down 21.0% 1990-2006 Avoided 767,000 cancer deaths over 16 yrs
Background image of page 4
The Crucial Influence of Heterogeneity The need to speak of “cancers” in the plural: the illusion of “The War on Cancer” (1970) The emergence of new signaling pathways, receptors, molecular targets, and mRNA and protein expression patterns The importance for research strategies on carcinogenic mechanisms, diagnosis, treatments, and preventive interventions The ramifications of subpopulation analysis and pharmaco-genomics
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Annual Age-Adjusted Cancer Incidence and Mortality Rates, 1975-2006
Background image of page 6
Cancer Incidence Rates for Selected Cancers by Sex, 1975-2006
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mortality Rates for Cancers and Heart Disease 1975-2006
Background image of page 8
Total Number of Cancer Deaths Avoided, 1991-2006
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cancer Prevention 1978 I was a member of the National Cancer Institute Advisory Board (NCAB) and deputy science adviser in the White House Office of NCAB pressed NCI to do more about prevention. Congress made representatives of federal regulatory agencies members of the NCAB. There was heightened attention to environmental hazards and to cancer prevention research.
Background image of page 10
The 1978 OSHA Hearings Bridbord K, Decoufle P, Fraumeni JF Jr, Hoel DG, Hoover RN, Rall DP, Saffiotti U, Schneiderman MA, Upton AC. Estimates of the fraction of cancer in the United States related to occupational factors. Testimony presented to Occupational Safety and Health Administration hearings, 15 September, 1978. Preceded by a press conference in April by Joseph Califano, HEW Secretary.
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Extrapolating from reported RR’s for just 6 of the presumably thousands of occupational and environmental chemical exposures—asbestos, arsenic, benzene, chromium, nickel, petroleum products—the scientists estimated that 23-38% of all cancers could be attributed to these six and proclaimed that future risks could be higher. Media coverage was intense. The Congressional Office of Technology
Background image of page 12
Image of page 13
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/23/2012 for the course SCI 310 taught by Professor Staff during the Fall '10 term at Rutgers.

Page1 / 79

43581-43591(1) - PREVENTABLE CAUSES OF CANCERS: REVISITING...

This preview shows document pages 1 - 13. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online