11-4-11_geneexpressionA

11-4-11_geneexpressionA - The power to destroy a planet is...

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Where? When? How much? Control of gene expression The power to destroy a planet is insignificant compared to the power to control midichlorian expression. Darth Vader, re-edit Think you have a young Jedi knight? Test your child at Yoda’s Midi-Mart, your genetic screen that’s faster than a Tie Fighter! Now available at Yoda’s Midi-Mart, Dagobah Juice, straight from the swamps of Dagobah, endorsed by Master Yoda himself to boost midichlorian count. “Look what it’s done for me!”, he says.
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Announcements CELLLS, part 1 due Monday, Nov. 7 at 5 pm .You may submit the assignment through Blackboard in Assignments Next exam is Monday, November 14 at 8 pm.
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Gene expression Gene expression is the process by which a gene's information is converted into functional products (like proteins, tRNA, rRNA) which are essential for maintaining the structures and functions of a cell. Gene expression is the most fundamental level at which Genotype gives rise to the Phenotype.
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How can we control the amount and timing of protein production? Control of promoter region by transcription factors and epigenetics Number of DNA copies of a given gene Control of RNA polymerase rate mRNA lifetime/stability Number of available ribosomes for translation Rate of amino acid attachment of peptide Protein lifetime/stability
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Three levels of control of gene expression Transcriptional-level control: whether and how often a gene can be transcribed Processing-level control: how a pre-mRNA is processed into a mature mRNA (e.g. alternative splicing) Translational-level control: whether and how often mRNA can be translated, also mRNA stability
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Cytosine methylation can suppress transcription and can be heritable across generations (epigenetics!) Constitutes 1% of all DNA bases . Found almost exclusively in the context of paired symmetrical methylation (methylation of both DNA strands of the dinucleotide CpG in repetitive DNA elements, or cytosine and guanosine linked by a phosphodiester bond, with GpC on the complementary strand. Hypermethylation and hypomethylation of heterochromatin reported in cancers. Heterochromatin
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11-4-11_geneexpressionA - The power to destroy a planet is...

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