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Lect2 - CrossoverNotes - CHL 5225 H Crossover Trials The...

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CHL 5225 H Crossover Trials The Two-sequence, Two-treatment, Two-period Crossover Trial Definition A trial in which patients are randomly allocated to one of two sequences of treatments (either 1 then 2, or 2 then 1) so that within-patient differences can be used to compare treatments ( i.e. patients can be used as their own control) Patients must stop the first treatment, and either start the second or enter a wash- t i d t d t i d i t i ti hi h i th f ll ti t out period, at a predetermined point in time, which is the same for all patients CHL 5225 H Crossover Trials Period 1 2 P ti t i P ti t i 1 2 Patient receives 1 Patient receives 2 Sequence (order) 2 1 Patient receives 2 Patient receives 1 2 1
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