6621 - Plasma Concentrations of Carotenoids, Retinol and...

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Unformatted text preview: Plasma Concentrations of Carotenoids, Retinol and Tocopherols in Preeclamptic and Normotensive Pregnant Women Cuilin Zhang Department of Epidemiology University of Washington, Seattle, USA BACKGROUND (1) • Preeclampsia- pregnancy induced hypertension and proteinuria – One of the common medical complications in pregnancy; – One of the leading causes of maternal mortality in pregnancy; – An important cause of premature delivery, fetal growth retardation, perinatal mortality. • Etiology & Pathogenesis – Unsolved mysteries; – Endothelial cell dysfunction appears to be the final common pathway in the pathogenesis of preeclampsia . Promote Evoke Scavenge Inhibit Free Radicals Reactive Oxygen Species Endothelial Cell Dysfunction Preeclampsia Antioxidants • Carotenoids • Retinol • Tocopherols Figure 1: Framework of the Biological Background of the Study BACKGROUND (2) Results from Previous Studies: – Imbalances between lipid peroxidation and antioxidant defenses in preeclampsia; – lower plasma α-carotene, β-carotene and retinol levels in preeclamptic women; α-tocopherol in preeclampia: parodoxical; – Reports concerning other lipid-soluble antioxidants in pregnancies complicated with preeclampsia are scarce; BACKGROUND (3) HYPOTHESIS OF THIS STUDY Plasma concentrations of fat-soluble vitamins or their precursors and related antioxidants are decreased in women with preeclampsia. OBJECTIVES Examine the relation of plasma concentrations of carotenoids, tocopherols and retinol with the risk of preeclampsia while the effects of potential confounding factors were evaluated. MATERIALS AND METHODS (1) • Case-control study • Conducted at the Maternal and Perinatal Hospital of Lima and the Dos de Mayo Hospital in Lima, Peru, June 1997 - January 1998. • Approved by the Ethical Committee of the Dos de Mayo Hospital, the Maternal Perinatal Hospital of Lima, and the Human Subjects Committee of the University of Washington Medical Center. • Potential study subjects - all new admissions to antepartum wards, emergency room wards, and labor and delivery wards of the study hospitals. Recruited during their hospital stay. MATERIALS AND METHODS (2) • Definition of Cases • Cases- women with a diagnosis of preeclampsia. • Preeclampsia was defined as: – persistent (i.e. lasting more than 6 hours) 15 mm Hg diastolic rise or a 30 mm Hg rise in systolic blood pressure, or – persistent blood pressures of at least 140/90 mm Hg. – and urine protein concentration ( 30 mg/dl or more (or 1+ on a urine dipstick) in at least two random specimens collected at least 4 hours apart. • 193 (97% of 199 eligible cases approached) cases agreed to participate the study. MATERIALS AND METHODS (3) Definition of Controls • Controls- pregnant women uncomplicated by pregnancy-induced hypertension or proteinuria....
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This note was uploaded on 02/23/2012 for the course PHARM 290 taught by Professor Staff during the Fall '10 term at Rutgers.

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6621 - Plasma Concentrations of Carotenoids, Retinol and...

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