8261 - Congenital malformations and birth weight: a family...

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Congenital malformations and birth weight: a family perspective Dr. Kari K.Melve Department of Public Health & Primary Health Care University of Bergen, Norway October, 2002
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Why is it fascinating to study families? Families constitute small ”populations” with shared genetic and environmental features Dependencies between family members have implications for risk assessment (for instance of adverse pregnancy outcome)
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Why is it fascinating to study birth defects? Birth defects account for a large proportion of perinatal and infant mortality The etiology of birth defects is in large not known 25 - 30 % of major birth defects may be attributed genetic factors
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Background for this study: There is a large and significant correlation between siblings’ birth weights Low birth weight tends to recur in sibships
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In general, infants with congenital malformations have lower mean birth weight than infants without malformations
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Growth restriction may be primary , predisposing the fetus for malformations … or secondary to the malformations ...or coexist with the malformations, and have common underlying causes
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Objective: To study birth weight of malformed infants’ siblings ..and compare with birth weight of infants in families without any registered malformations
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This note was uploaded on 02/23/2012 for the course PHARM 290 taught by Professor Staff during the Fall '10 term at Rutgers.

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8261 - Congenital malformations and birth weight: a family...

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