8771 - MAGNESIUM DISCUSSION PRO AND CON Eugene Yevstratov...

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MAGNESIUM DISCUSSION PRO AND CON MAGNESIUM SHOULD BE ADMINISTERED TO   ALL   CORONARY ARTERY BYPASS GRAFT SURGERY   PATIENTS UNDERGOING   CARDIOPULMONARY BYPASS ? Eugene Yevstratov MD
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Mg +  as an element Cofactor for more than 260 enzymes Required for oxidative metabolism Required for protein syntesis Required for maintenace of ion cell balance A normal function of ion pumps  
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Mg  +  administration (pro) Eliminate the deleteriouse effects of  hypomagnesemia (a common, often  unrecognized condition in cardiac  surgical patients) Decrease myocardial insult induced  during aortic crossclamp Decrease the incidence of postoperative  arrhythmias
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Some effects of myocardial  ischemia and reperfusion Increased intracellular calcium Production of oxygen – derived  free radicals Depletion of high energy  phosphates
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Mg +  action site Magnesium is an inorganic calcium channel blocker
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This note was uploaded on 02/23/2012 for the course PHARM 290 taught by Professor Staff during the Fall '10 term at Rutgers.

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8771 - MAGNESIUM DISCUSSION PRO AND CON Eugene Yevstratov...

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