12781 - Validation / citations Validation Expert review of...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Validation / citations Validation Expert review of model structure Expert review of basic code implementation Reproduce original inputs Correctly respond to changes in parameters Consistent with other analyses Consistent across versions Documentation specifications Validation requires adequate documentation to Describe clinical model Describe programming algorithms Describe inputs (sources / values / data quality) Describe validation strategy Citations Basic rationale and structure-- Matchar et al., Annals of Internal Medicine (1997) Bootstrapped sensitivity analysis-- Parmigiani et al., Medical Decision Making (1997) Application to acute stroke trial-- Samsa et al., Journal of Clinical Epidemiology (in press) Outline Rationale for modeling Stroke model described Applying the SPM to a randomized trial (*) Extensions Applying the SPM to an RCT Basic idea : After the short follow-up period typical of an RCT, we are likely to observe that the intervention induces small shifts in the distribution of morality / disability (measured at the conclusion of follow-up). Modeling can be used to account for the effects of these shifts on long-term outcomes. Disability measure Disability could be measured by the Rankin Scale (RS), Barthel Index (BI), or a number of other instruments. For concreteness, we use the RS with 5 categories. The analysis easily extends to other scales and/or cut-points. Risk (hazard) ratios for disability on subsequent outcomes* RS Utility h(IS) h(MI) h(DT) Cost 0-1...
View Full Document

This note was uploaded on 02/23/2012 for the course PHARM 290 taught by Professor Staff during the Fall '10 term at Rutgers.

Page1 / 27

12781 - Validation / citations Validation Expert review of...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online