13831 - The Vicious Cycle of Chronic Congestive Heart...

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The Vicious Cycle of Chronic Congestive Heart Failure
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Spironolactone
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Overflow and Underfilling Hypotheses of Sodium and Water Retention in Cirrhosis
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PERIPHERAL ARTERIAL VASODILATION HYPOTHESIS Peripheral Arterial Vasodilation Plasma Hormones (AVP, Renin, Aldosterone, NE) Plasma Volume COMPENSATED CIRRHOSIS (No Ascites) DECOMPENSATED CIRRHOSIS (Ascites) Hepatorenal Syndrome Normal
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Hypothalamic AVP-mRNA of Control and Cirrhotic Rats
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“I have ascites and have desire for water, Although I know this water will kill me.” Rami (1226-1294 A.D.)
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Effects of Non-Peptide AVP Antagonist in Liver Cirrhosis
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Effect of V1-Vasopressin Antagonist on Arterial Blood Pressure in Experimental Cirrhosis in Rats
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ALDOSTERONE ANTAGONISM PROMOTES WEIGHT LOSS AND DISAPPEARANCE OF ASCITES IN DECOMPENSATED CIRRHOSIS PARAMETER Death Weight loss (lb) Disappearance of ascites CONTROL (n-22) 7 6 + 2 4 SPIRONOLACTONE (n=21) 5 24 + 4 16 CIRRHOTIC PATIENTS Gregory et al., 1977
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Delivery with Mannitol Resulted in a Marked Natriuresis During ANP Infusion
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13831 - The Vicious Cycle of Chronic Congestive Heart...

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