13881 - Congenital Syphilis Irina Tabidze, MD, MPH and Thad...

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Congenital Syphilis Congenital Syphilis Irina Tabidze, MD, MPH  Irina Tabidze, MD, MPH  and and Thad Zajdowicz, MD, MPH Thad Zajdowicz, MD, MPH STD/HIV Division STD/HIV Division Chicago Dept of Public Health Chicago Dept of Public Health
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Congenital Syphilis (CS) Congenital Syphilis (CS) Syphilis is a chronic infection caused by  the spirochete  Treponema pallidum , which  is of particular concern during pregnancy  because of the risk of transplacental  infection of the fetus.  Congenital infection is associated with  several adverse outcomes, including: -Perinatal death -Premature delivery -Low birth weight -Congenital anomalies
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Modes of Transmission: Modes of Transmission: Sexual contact. Trans-placental passage from  infected mother. Contact with lesion at the time of  delivery. The risk of developing syphilis after  exposure is about 40%.
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Risk Factors for CS Risk Factors for CS Lack of  or inadequate prenatal care. Maternal substance abuse.  Failure to repeat a serological test for  syphilis in the third trimester. Treatment failure. Inadequate access to Sexually  Transmitted Diseases (STD) clinics and  STD outreach activities.
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Epidemiology of CS Epidemiology of CS Incidence of CS reflects the rate of  syphilis in women of childbearing age.  Peaks in CS occur one year after peaks  in P&S syphilis in women.
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This note was uploaded on 02/23/2012 for the course PHARM 290 taught by Professor Staff during the Fall '10 term at Rutgers.

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13881 - Congenital Syphilis Irina Tabidze, MD, MPH and Thad...

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