15311 - University of California,San Francisco 1 Department...

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Unformatted text preview: University of California,San Francisco 1 Department of Anesthesia and Perioperative Care Department of Anesthesia and Perioperative Care Acute P. aeruginosa Infections- From Genes to the Bedside The relationship between research and clinical care Jeanine Wiener-Kronish, M.D. Professor of Anesthesia and Medicine Vice Chair, Department of Anesthesia and Perioperative Care University of California,San Francisco 2 Department of Anesthesia and Perioperative Care Department of Anesthesia and Perioperative Care OBJECTIVES Review Pseudomonas aeruginosa infections and importance of virulence factors in infections Review research into mechanisms of Pseudomonas aeruginosa induction of lung injury Translation of basic research to patients-are the experimental data relevant to lung injury in patients?? University of California,San Francisco 3 Department of Anesthesia and Perioperative Care Department of Anesthesia and Perioperative Care Pseudomonas aeruginosa infections Leading cause of gram negative nosocomial pneumonias and bacteremia in adults and children ** S. aureus more commonly associated with bacteremia, but P. aeruginosa bacteremia associated with increased mortality and increased organ dysfunction Ped Infect Dis J 2003: 22:686-91 Chest 2004;125:607-616 J Hosp Infect 2003;53:18-24 University of California,San Francisco 4 Department of Anesthesia and Perioperative Care Department of Anesthesia and Perioperative Care Other P.aeruginosa infections Bacteremia in AIDS External otitis in diabetics and patients obtaining posts through ear cartilage Contact lens keratitis Long term pulmonary infections in CF Urinary infections CAP- 3rd most common agent in Spain JAMA 2004;291:981-5; Curr Opin Infect Dis 2003;16: 135-143 University of California,San Francisco 5 Department of Anesthesia and Perioperative Care Department of Anesthesia and Perioperative Care Why is P.aeruginosa successful? Infections with P.aeruginosa are severe, unrelenting and are associated with high mortalities--is it because the hosts are so sick or is it because the bacteria is so virulent?? P.aeruginosa also colonizes--are the same strains of P.aeruginosa causing colonization and infections?? University of California,San Francisco 6 Department of Anesthesia and Perioperative Care Department of Anesthesia and Perioperative Care P. aeruginosa Virulence List of cell associated virulence factors : Type IV fimbriae, LPS, non-fimbrial adhesins,...
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This note was uploaded on 02/23/2012 for the course PHARM 290 taught by Professor Staff during the Fall '10 term at Rutgers.

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15311 - University of California,San Francisco 1 Department...

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