15351 - Many problems with transfusions are related to...

Info iconThis preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon
Many problems with transfusions are related to infection. In 1985, the chance for hepatitis was 10% and HIV 0.5%
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
TABLE 47-11 Percentage Risk of Transfusion-Transmitted Infection With a Unit of Screened Blood in the United States RISK WINDOW PERIOD (DAYS) HIV 1/800,000 22 11 1/641,000 51 Cytomegalovirus < 1.0% rapidly HCV 1/600,000 82 8-10 HBV 1/200,000 59 HIV human immunodeficiency virus type 1: HTLV human T-cell lymphotropic virus: HCV hepatitis C virus: HBV hepatitis B virus
Background image of page 2
TABLE 47-12 Infectious Disease Testing For Blood Transfusions (1998) 1. Discontinue serum alanine aminotransferase testing 2. Hepatitis C antibody testing 3. Antibody to hepatitis B core antigen 4. HIV-1 5. HIV-2 6. HIV Ag (p24 antigen) 7. HTLV I/II 8. Serologic test for syphilis) From JAMA 1995;274:1374 HIV, human immunodeficiency virus:HTLV, human T-cell lymphotropic virus
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
IMPROVE TESTING Molecular testing Viral inactivation
Background image of page 4
TABLE 47-13 Tests Used For Detecting Infectious Agents In All Units Of Blood (2004) VIRUS RNA MINPOOL ANTIBODY TO HIV NAT HCV NAT HCV HBV HBC HTLV WNV NAT NAT = nucleic acid technology WNV = West Nile Virus HIV human immunodeficiency virus type 1: HTLV human T-cell lymphotropic virus: HCV hepatitis C virus: HBV hepatitis B virus
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
NUCLEIC ACID TECHNOLOGY (NAT) TESTING WILL BE USED ON: HBV Hepatitis A Parvovirus 19 West Nile Virus
Background image of page 6
TABLE 47-14 INFECTIOUS DISEASES (2004) - NO TEST DISEASE RISK Malaria 2-3 cases per year in USA Chagas 0.1 -0.2% of units SARS ? VCJD ? V CJD = Variant Creutzfeldt-Jakob Disease SARS = Severe Acute Respiratory Syndrome
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
*DONATED BLOOD WILL BE BANNED FROM DONORS WHO: Lived in UK 3 months or longer since 1980 Lived in Europe 6 months since 1980 Anyone who has received blood in UK Will decrease donors by 8-9% * American Red Cross
Background image of page 8
MALARIA 2 to 3 cases/year for 40 years Since 1982, all cases were from emigrants or residents from endemic areas
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
WEST NILE VIRUS 4,000 cases of which 21 are transmitted by transfusion* In 2002, 23 cases** 43% were immunocompromised 8% were > 70 years Science 2003; 299:1824 ** N Engl J Med 2003; 349:1236
Background image of page 10
TABLE 47-8 TRANSFUSION FATALITIES (2001-2002) IN THE UNITED STATES* Bacterial contamination - 17 TRALI - 16 Mistransfusion - ABO mismatch - 14 *From the Federal Drug Administration (Oct. 1, 2001 to September, 30, 2002) TRALI = transfusion related acute lung injury
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
33 year old male with chronic pancytopenia from failed allogeneic bone marrow Tx Platelets caused hypotension refractory to pressor respiratory failure, acidosis, etc.
Background image of page 12
Image of page 13
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 53

15351 - Many problems with transfusions are related to...

This preview shows document pages 1 - 13. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online