16481 - Hierarchy of Clinical Evidence Systematic Reviews...

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Physiologic Studies Physiologic Studies Intuition or Beliefs Intuition or Beliefs Systematic Reviews Systematic Reviews Metaanalysis Metaanalysis Double-blind Double-blind Randomized Controlled Trials Randomized Controlled Trials Cohort Studies Cohort Studies Case-Control Case-Control St St udies udies Cases Report/Series Cases Report/Series Hierarchy of Clinical Evidence Hierarchy of Clinical Evidence O b s e r v a t i o n l
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Design of a cohort study TIME direction of inquiry people exposed disease population without the no disease disease not exposed disease no disease “at risk”
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Design of a case-control study TIME direction of inquiry Start with: Exposed cases (people with disease) Not exposed Population Exposed controls (people without disease) Not exposed
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Questions to ask when an association is reported in the literature (eg estrogen and CHD) Explanation Finding Association Bias in selection Yes No or measurement Chance Likely Unlikely Confounding Yes No Cause Cause
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This note was uploaded on 02/23/2012 for the course PHARM 290 taught by Professor Staff during the Fall '10 term at Rutgers.

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16481 - Hierarchy of Clinical Evidence Systematic Reviews...

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