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17791 - Oxidant Mechanisms in Response to Ambient Air...

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Oxidant Mechanisms in Response to Ambient Air Particles Beatriz González-Flecha Department of Environmental Health Harvard School of Public Health Boston, MA, USA
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Rats Mice Paramecia Oxygen toxicity: early evidence Mice Drosophila Rats Paramecia
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Oxygen poisoning and X-irradiation: A mechanism in common R. Gershman et al. Nature , 1954 First demonstration of the involvement of oxygen free radicals in the mechanism of oxygen toxicity
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Oxygen Free Radicals = Reactive Oxygen Species (ROS) O 2 e - e - e - e - O 2 -. H 2 O 2 HO H 2 O Produced in association to aerobic metabolism (1952)(1970’s) Toxic at high concentrations (1954) (1970’s) Able to promote cell proliferation and enzyme induction at sublethal concentrations (1962)(1990) Superoxide anion Hydrogen peroxide Hydroxyl radical
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Main sources of ROS in mammalian tissues Intracellular source Species 1. Mitochondrial Respiratory Chain Ubiquinone O 2 -. NADH dehydrogrenase O 2 -. 2. Enoplasmic Reticulum NADH-cytochrome reductase O 2 -.
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