19981 - The Metabolic Syndrome: International Diabetes...

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Paul Zimmet & George Alberti Paul Zimmet & George Alberti Co-Chairmen Co-Chairmen The Metabolic Syndrome: International Diabetes Federation (IDF) consensus definition
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METABOLIC SYNDROME A cluster of risk factors for diabetes and cardiovascular disease
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The Metabolic Syndrome A cluster of risk factors for diabetes and cardiovascular disease consisting of: Central (abdominal) obesity Diabetes, IFG and IGT Hypertension Dyslipidaemia (“Deadly Quartet”)
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International Diabetes Federation (IDF) consensus definition In 2004, the IDF held an expert workshop to examine how the currently available definitions for the Metabolic Syndrome could be improved and developed with the aim of reaching a consensus for the introduction of a new and unifying definition.
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THE ORIGINS 1920s 1940s/50s – Vague 1967 – Avogaro & Crepaldi 1988 - Reaven
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Kylin E: Studien ϋber das Hypertonie-Hyperglykämie – Hyperurika miesyndrome 1923 Kylin 1923 Description
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“seems to suggest a peculiar syndrome including hyperlipemia, obesity and diabetes. The development of ischaemic heart disease … and hypertension is often found in these patients.” Avogaro & Crepaldi, 1965 Crepaldi 1965 Description
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The 2000 WHO Working Group attempt to describe & define the Metabolic Syndrome was an initiative to create interest and debate – it was never meant to be the final answer.
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Metabolic Syndrome – WHO 1999 At least 1 of At least 1 of Type 2 diabetes Type 2 diabetes IGT IGT Insulin resistance Insulin resistance Type 2 diabetes Type 2 diabetes IGT IGT Insulin resistance
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This note was uploaded on 02/23/2012 for the course PHARM 290 taught by Professor Staff during the Fall '10 term at Rutgers.

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19981 - The Metabolic Syndrome: International Diabetes...

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