33701 - Cardiometabolic Syndrome Dr Nabil Sulaiman HOD...

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Cardiometabolic Syndrome Dr. Nabil Sulaiman HOD Family and Community Medicine, Sharjah University and University of Melbourne Dr Dhafir A. Mahmood Consultant Endocrinologist Sharjah
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Agenda Clustering component of Metabolic Syndrome Cardiovascular disease worldwide Global cardiometabolic risks Abdominal obesity prevalence ( National & International ) Targeting Cardiometabolic Risk factors Multiple Risk Factor management A Critical Look at the Metabolic Syndrome
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Metabolic Syndrome (History Metabolic Syndrome (History ) ) 1923 - Kylin first to describe the clustering of hypertension, hyperglycemia, hyperuricemia 1936 - Himsworth first reported Insulin insensitivity in diabetics 1965 - Yalow and Berson developed insulin assay and correlated insulin levels & glucose lowering effects in resistant and non-resistant individuals
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Metabolic Syndrome History Metabolic Syndrome History (cont (cont 1988 - Reaven in his Banting lecture at the ADA meeting coined the term Syndrome X and brought into focus the clustering of features of Metabolic Syndrome Reaven now prefers the name, Insulin- Resistance Syndrome - feels insulin resistance is the common denominator for Metabolic Syndrome Literature now extensive
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Other Names Used Other Names Used : : Syndrome X Cardiometabolic Syndrome Cardiovascular Dysmetabolic Syndrome Insulin-Resistance Syndrome Metabolic Syndrome Beer Belly Syndrome Reaven’s Syndrome etc.
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Clustering of Components Clustering of Components : : Hypertension: BP. > 140/90 Dyslipidemia: TG > 150 mg/ dL ( 1.7 mmol/L ) HDL- C < 35 mg/ dL (0.9 mmol/L) Obesity (central): BMI > 30 kg/M2 Waist girth > 94 cm (37 inch) Waist/Hip ratio > 0.9 Impaired Glucose Handling: IR , IGT or DM FPG > 110 mg/dL (6.1mmol/L) 2hr.PG >200 mg/dL(11.1mmol/L) Microalbuninuria (WHO)
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Necessary Criteria to Make Diagnosis Necessary Criteria to Make Diagnosis WHO: WHO: Impaired G handling + 2 other criteria. Impaired G handling + 2 other criteria. Also requires microalbuminuria - Albumen/ creatinine ratio >30 mg/gm creatinine IDF: IDF: Require central obesity plus two of the other abnormalities NCEP/ATP III: NCEP/ATP III: Require three or more of the five criteria
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What is cardiometabolic risk ?* Global cardiometabolic risk represents the overall risk of developing type 2 diabetes and/or cardiovascular disease (including MI and stroke±, which is due to a cluster of modifiable risk factors/markers These include classical risk factors such as smoking, high LDL, hypertension, elevated blood glucose and emerging risk factors closely related to abdominal obesity (especially intra-abdominal adiposity±, such as insulin resistance, low HDL, high triglycerides and inflammatory markers Cardiometabolic risk is based on the Cardiometabolic risk is based on the
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This note was uploaded on 02/26/2012 for the course PHARM 210 taught by Professor Staff during the Fall '10 term at Rutgers.

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33701 - Cardiometabolic Syndrome Dr Nabil Sulaiman HOD...

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