33711 - :Linked Metabolic Abnormalities Linked Impaired...

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Linked Metabolic Abnormalities Linked Metabolic Abnormalities : : Impaired glucose handling/ insulin resistance Atherogenic dyslipidemia Endothelial dysfunction Prothrombotic state Hemodynamic changes Proinflammatory state Excess ovarian testosterone production Sleep-disordered breathing
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Resulting Clinical Conditions Resulting Clinical Conditions : : Type 2 diabetes Essential hypertension Polycystic ovary syndrome (PCOS) Nonalcoholic fatty liver disease Sleep apnea Cardiovascular Disease (MI, PVD, Stroke) Cancer (Breast, Prostate, Colorectal, Liver)
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Multiple Risk Factor Management Multiple Risk Factor Management Obesity Glucose Intolerance Insulin Resistance Lipid Disorders Hypertension Goals: Goals: Minimize Risk of Type 2 Minimize Risk of Type 2 Diabetes and Cardiovascular Disease Diabetes and Cardiovascular Disease
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Glucose Abnormalities Glucose Abnormalities : : IDF: IDF: FPG >100 mg/dL (5.6 mmol. L) or previously diagnosed type 2 diabetes WHO: WHO: Presence of diabetes, IGT, IFG, insulin resistance ATP III: ATP III: FBS >110 mg/dL, <126 mg/dL (6.1-7.1 mmol/L ) (ADA: FBS >100 mg/dL [ 5.6 mmol/L ])
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Hypertension Hypertension : : IDF: IDF: BP >130/85 or on Rx for previously diagnosed hypertension hypertension WHO: WHO: BP >140/90 NCEP ATP III: NCEP ATP III: BP >130/80
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Dyslipidemia Dyslipidemia : : IDF: IDF: Triglycerides - >150mg/dL (1.7 mmol /L) HDL - <40 mg/dL (men), <50 mg/dL (women) WHO: WHO: Triglycerides - >150 mg/dL (1.7 mmol/L) HDL - <35 mg/dL (men), >39 mg/dL) women ATP III: ATP III: Same as IDF
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Adipocytokines and Insulin Resistance Adipokines and Metabolic Syndrome
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Insulin Glut 4 NO MAPK IRS-1 PI-3K IL-1 IL-6 TNF α CCR-2 MMP VCAM PAI-1 VEGF Growth Transcription Factors INSULIN MODULATION OF ENDOTHELIAL ACTIVITIES
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Insulin Resistance Insulin Resistance : : Hyperinsulinemic individuals are at risk for developing Diabetes, Dyslipidemia, Hypertension
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This note was uploaded on 02/26/2012 for the course PHARM 210 taught by Professor Staff during the Fall '10 term at Rutgers.

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33711 - :Linked Metabolic Abnormalities Linked Impaired...

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