33751 - Cardiometabolic Syndrome Nabil Sulaiman HOD Family...

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Cardiometabolic Syndrome Nabil Sulaiman HOD Family and Community Medicine, Sharjah University and University of Melbourne & Dr Dhafir A. Mahmood Consultant Endocrinologist Al- Qassimi & Al-Kuwait Hospital Sharjah
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Cardiometabolic Syndrome II Aims Abdominal obesity prevalence Targeting Cardiometabolic Risk factors Multiple Risk Factor management A Critical Look at the Metabolic Syndrome
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Clustering of Components Clustering of Components : : Hypertension: BP. > 140/90 Dyslipidemia: TG > 150 mg/ dL ( 1.7 mmol/L ) HDL- C < 35 mg/ dL (0.9 mmol/L) Obesity (central): BMI > 30 kg/M2 Waist girth > 94 cm (37 inch) Waist/Hip ratio > 0.9 Impaired Glucose Handling: IR , IGT or DM FPG > 110 mg/dL (6.1mmol/L) 2hr.PG >200 mg/dL(11.1mmol/L) Microalbuninuria (WHO)
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Global cardiometabolic risk * Gelfand EV et al , 2006; Vasudevan AR et al , 2005 * working definition
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The new IDF definition focusses on abdominal obesity rather than insulin resistance International Diabetes Federation (IDF) Consensus Definition 2005
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Why a New Definition of the MeS: IDF Objectives Needs: To identify individuals at high risk of developing cardiovascular disease (and diabetes) To be useful for clinicians To be useful for international comparisons
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Central Obesity Central Obesity IDF: IDF: Central obesity - waist circumference >94 cm for Europid men, >80 Europid women with ethnicity specific values for other groups WHO: WHO: Waist-hip ratio >0.9 - men or >0.85 - women ATP III: ATP III: Waist circumference >40 in. - men, > 35 in. - women
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Fat Topography In Type 2 Diabetic Subjects Intramuscular Intrahepatic Subcutaneous Intra- abdominal FFA * TNF-alpha * Leptin * IL-6 (CRP) * Tissue Factor * PAI-1 * Angiotensinogen *
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Abdominal obesity and increased risk of
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33751 - Cardiometabolic Syndrome Nabil Sulaiman HOD Family...

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