40101 - Epidemic of Cardiovascular disease Global and US...

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Epidemic of Cardiovascular disease Global and US trends Any Lessons for Honduras? Dr. Thomas G. Allison Cardiovascular Diseases and Internal Medicine Mayo Clinic Rochester, MN
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Disclosures Conflicts of interest: none Off-label use of drugs or devices: none
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Global Burden of Cardiovascular Disease Developing countries 80% of worldwide CV deaths Occur at a younger age 2010 – 70% of the elderly will live in the developing world Total deaths – 57 million Cardiovascular 16.7 million HIV TB Malaria 5 million Lopez. Lancet 2006; Reddy. NEJM 2004 2002 statistics
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International Comparison 170 183 212 289 413 557 714 1555 0 200 400 600 800 1000 1200 1400 1600 Japan France Canada USA Rural China Poland Hungary Russia CVD Death Rates/100,000 (Men ages 35-74)
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Cardiovascular Disease in the Americas
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Highest Lowest
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Life Expectancy in the Americas Haiti: 55 years Guyana: 63 years Bolivia: 65 years Honduras: 67 years Brazil: 70 years Peru: 71 years Jamaica: 72 years Paraguay: 72 years Columbia: 73 years Mexico: 74 years Argentina: 75 years Uruguay: 75 years Panama: 76 years Costa Rica: 77 years Chile: 77 years Cuba: 78 years USA: 78 years Canada: 80 years
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Modified Model of the Epidemiological Transition as it Pertains to Cardiovascular Disease Yusef et al. Circulation 2001;104:276-2753
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Stage 1: Age of Pestilence and Famine Life expectancy < 55 years CVD deaths 5-10% of total deaths < 5% of years of life lost (YLL) Prominent CV diseases and risk factors Rheumatic heart disease, infections, nutritional cardiomyopathies Regional examples Sub-Saharan Africa, rural India, Haiti
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Stage 1: Haiti Life expectancy = 55 years
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Causes of Death Haiti 2002 Cause of Death Deaths YLL HIV/AIDS 22% 20% Lower respiratory infections 7% 9% Cerebrovascular disease 6% 3% Meningitis 5% 7% Diarrheal diseases 5% 7% Perinatal conditions 4% 7% Tuberculosis 4% 4% Hypertensive heart disease 3% 1% Anemia 3% 4% Diabetes mellitus 3% 1%
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Stage 2: Age of Receding Pandemics Life expectancy 55-65 years CVD deaths 10-35% of total deaths Prominent CV diseases and risk factors Rheumatic heart disease, infections, nutritional
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This note was uploaded on 02/26/2012 for the course PHARM 210 taught by Professor Staff during the Fall '10 term at Rutgers.

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40101 - Epidemic of Cardiovascular disease Global and US...

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