40211 - How Much Exercise Is Necessary to Prevent CV...

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How Much Exercise Is Necessary to Prevent CV Disease? Thomas G. Allison, PhD, MPH Mayo Clinic, Rochester, MN, USA
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Exercise Prevention of CHD Amount of exercise? Exercise intensity? Type of exercise?
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The relationship between exercise or physical fitness and CHD is curvilinear 0 50 100 150 200 250 300 350 400 Annual CHD Mortality/100,000 None 360 720 1080 1440 1800 2160 2520 kcal of Exercise per Week – CHD risk = f(1/x)
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0 50 100 150 200 250 300 350 400 Age 70-84 Age 60-69 Age 50-59 Age 35-49 Relationship of Leisure-Time Physical Activity to All-Cause Mortality in Male Harvard Alumni < 500 kcal/week 500-1999 kcal/week 2000+ kcal/week Benefits of Exercise Increase with Age (and Risk)
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CHD Risk Factor Trends in US Risk factors declining since 1980 Smoking LDL cholesterol Risk factors increasing since 1980 Obesity Diabetes/IFG Low HDL cholesterol High triglycerides Sedentary lifestyle Not strongly associated with exercise/physical activity Strongly associated with exercise/physical activity
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Physical Activity and All-cause Mortality In Iowa Women Prospective cohort study of 40,417 women Aged 55-69 years at baseline Followed 7 years Physical activity assessed by mailed questionnaire Kushi et al, JAMA 1997;277:1287-1292
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