40211 - How Much Exercise Is Necessary to Prevent CV...

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Unformatted text preview: How Much Exercise Is Necessary to Prevent CV Disease? Thomas G. Allison, PhD, MPH Mayo Clinic, Rochester, MN, USA Exercise Prevention of CHD Amount of exercise? Exercise intensity? Type of exercise? The relationship between exercise or physical fitness and CHD is curvilinear 50 100 150 200 250 300 350 400 Annual CHD Mortality/100,000 None 360 720 1080 1440 1800 2160 2520 kcal of Exercise per Week – CHD risk = f(1/x) 50 100 150 200 250 300 350 400 Age 70-84 Age 60-69 Age 50-59 Age 35-49 Relationship of Leisure-Time Physical Activity to All-Cause Mortality in Male Harvard Alumni < 500 kcal/week 500-1999 kcal/week 2000+ kcal/week Benefits of Exercise Increase with Age (and Risk) CHD Risk Factor Trends in US Risk factors declining since 1980 • Smoking • LDL cholesterol Risk factors increasing since 1980 • Obesity • Diabetes/IFG • Low HDL cholesterol • High triglycerides • Sedentary lifestyle Not strongly associated with exercise/physical activity Strongly associated with exercise/physical activity Physical Activity and All-cause Mortality In Iowa Women • Prospective cohort study of 40,417 women • Aged 55-69 years at baseline • Followed 7 years • Physical activity assessed by mailed questionnaire Kushi et al, JAMA 1997;277:1287-1292 All-cause Mortality In Iowa Women Related to...
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This note was uploaded on 02/26/2012 for the course PHARM 210 taught by Professor Staff during the Fall '10 term at Rutgers.

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40211 - How Much Exercise Is Necessary to Prevent CV...

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