mock32011-2-ans

mock32011-2-ans - 1) What are the roles of protein kinase A...

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1) What are the roles of protein kinase A in the response of a liver cell to epinephrine? Answer: PKA has a least three roles: 1) To phosphorylate and inactivate glycogen synthase – leading to inhibition of glycogen synthesis 2) To phosphorylate and activate phosphorylase kinase – leading to glycogen breakdown 3) To phosphorylate and activate CREB, leading to new protein synthesis 2) Compare and contrast olfactory transduction with phototransduction Answer: Similarities: Both occur in modifies cilia, both use G-protein linked receptors, both use cyclic nucleotides as messengers which open ion channels Differences, photoreception uses retinal to absorb light and a different member of the 7- transmembrane domain receptor family from that used in olfaction. In phototransduction, the G-protein activates a phosphodiesterase, not a cyclase, so cyclic nucleotide levels drop rather than increase as in olfaction. Olfaction uses cAMP as its cyclic nucleotide messenger, not cGMP 3) Why does a molecule that binds to the ryanodine receptor bock calcium waves inside a
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This note was uploaded on 02/27/2012 for the course BSCI 330 taught by Professor Payne during the Spring '08 term at Maryland.

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mock32011-2-ans - 1) What are the roles of protein kinase A...

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