CN2010 Membrane Physiology - Problem Set 2

CN2010 Membrane Physiology - Problem Set 2 - PROBLEM SET 2...

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September 21 Due at start of class September 28 The problems are open book, but not collaborative. A key will be posted after lecture on the Tuesday the problems are due, so late submissions will not be accepted. These problem sets will replace in-class quizzes. Problem 3 Cell equivalent circuits We are studying the a cell in the hypothalamus of the ground squirrel. It is likely to be a secretory cell, as it is spherical and has no processes. We have found that the cell has a conductance which can be rapidly activated by somatostatin. The equivalent circuit for the cell is: We measure the resting potential and the steady-state potential in the presence of somatostatin (with switch S closed). We also inject current into the cell to measure the membrane time constant in the presence and absence of somatostatin. A. We start by studying young adult animals. At rest: V R = -60 mV g R = 3 x 10 -9 S τ R = 33.3 ms (0.0333 sec) A1. What is the membrane capacitance (C M )? We then study the response to somatostatin.
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This note was uploaded on 02/27/2012 for the course BIO 5571 taught by Professor P.taghert during the Fall '11 term at Washington University in St. Louis.

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CN2010 Membrane Physiology - Problem Set 2 - PROBLEM SET 2...

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