CN2011 Exam 3 Key - Name:_ Cellular Neurobiology Biology...

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Name:___________________ Exam # Cellular Neurobiology Biology 5571 Examination #3 December 13, 2011 Instructions Due Date - This exam is due by 10:30 AM Thursday December 15, in class or in Paul Taghert’s office (469 McDonnell Sciences). Sources - The exam is open book//open source. - You may not discuss it with anyone. - Please refer questions to Alejandro, or to any of the seven lecturers. Pages - Start each question on a new sheet of paper and put your assigned number (not name) at the top of each page you submit. - You can write on the pages provided or use your own blank sheets. - Don’t exceed page limits; limits assume use of double line spacing. - Some questions request you show all your work – partial credit may be given. - Illegible answers will receive no credit. Point Distribution The exam totals 100 points: Develop. Neurobiology Question 1 8 pts Question 2 8 pts Question 3 3 pts Question 4 7 pts Question 5 7 pts Circadian Neurobiology Question 6 8 pts Question 7 5 pts Question 8 11 pts Question 9 3 pts Question 10 3 pts Question 11 3 pts Neurobiology of Disease Question 12 8 pts Question 13 12 pts Question 14 14 pts
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Name:___________________ Exam # 1. (8 pts) Developmental Neurobiology (½ page) Describe the concept of critical periods in the development of the nervous system. Give one example. Describe a set of experiments to determine if there are critical periods for the olfactory system. The concept of a critical period implies that that there is a window in time where some input is essential to normal development of a system. In the visual system monocular deprivation during early visual experience will result in a reduction in the number of cells responding to input to the deprived eye in the visual cortex. If there were a critical period in the olfactory system, then depriving input to this system would somehow alter the development of the system. There are a lot of ways to potentially test this idea. Key features of any experiments should include some kind of reversible method of stopping input to the olfactory system, and some assay for the function of the system . Either electrophysiological methods for measuring the ability of neurons in olfactory circuitry to respond do differential odors, or behavioral assays of the animal’s ability to distinguish odors could be acceptable approaches.
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Name:___________________ Exam # 2. (8 pts) Developmental Neurobiology (½ page) Assume your experiments did establish that the olfactory system has critical periods. Based on other systems, what would be two reasonable hypotheses for molecular mechanisms of critical periods? How would you test these hypotheses? Again, there are a lot of answers that could be appropriate here. Certainly NMDA receptor activation would be reasonable, as would remodeling of extra-cellular matrix, or development of neural nets. For experiments, we are looking for clear reasoning using either chemical or genetic
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This note was uploaded on 02/27/2012 for the course BIO 5571 taught by Professor P.taghert during the Fall '11 term at Washington University in St. Louis.

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CN2011 Exam 3 Key - Name:_ Cellular Neurobiology Biology...

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