CN2011 Synapses Homework #2 Answers

CN2011 Synapses Homework #2 Answers - Synapses Homework 2....

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Synapses Homework 2. Due 10/13 1. The following figure is from the first chapter on basic pharmacology in “Molecular Pharmacology. A Foundation for Clinical Neuroscience” by Nestler, Hyman, & Malenka (three prominent neuroscientists). What is wrong with the figure and description? Explain how the error might lead to misleading interpretations of experiments. Hint: Consider Colquhoun’s critique of the pharmacology literature. [To be fair, this text is aimed at clinicians more than at research scientists] The figure relates the log of the drug concentration to biological effect, defined here as percentage of maximal response. You can directly measure potency/EC50 (effective agonist concentration that produces 50% of maximal response) from this chart but not the affinity/dissociation constant (K d ) which is based on the drug’s binding properties and not a functional response. 2. Describe a glutamate silent synapse. How is it typically defined (identified)? How is this phenomenon problematic for Katz’s quantal hypothesis? A glutamate silent synapse has postsynaptic NMDARs and no AMPARs, so under
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This note was uploaded on 02/27/2012 for the course BIO 5571 taught by Professor P.taghert during the Fall '11 term at Washington University in St. Louis.

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CN2011 Synapses Homework #2 Answers - Synapses Homework 2....

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