Lecture 5 - position 6 in the gene encoding the - subunit...

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How Genes Work Gene expression as protein synthesis 1
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You should be able to… Explain the relationship between gene, RNA and polypeptide (the Central Dogma) Compare errors in transcription to those in translation Use the genetic code to translate nucleic acid sequences into polypeptide chains Explain the significance of the different types of mutations discussed in class Explain dominant-recessive relationships 2
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The Central Dogma = Gene Expression = Protein Synthesis 3
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Metabolic Pathways and the “1- Gene, 1-Enzyme” Hypothesis 4 Enzyme A Enzyme B Enzyme C
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Changes in genotype cause changes in phenotype… 5
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Sickle Cell Anemia 6 What determines whether Glu or Val is in the 6th position?
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Sickle Cell Trait Condition where an individual has only one allele coding for an abnormal hemoglobin protein Review: Sickle cell disease Autonomal Recessive disorder Chromosome 11 Change from Glutamic Acid to Valine at
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Unformatted text preview: position 6 in the gene encoding the - subunit of Hemoglobin Symptoms Most are asymptomatic Problems during exercise/overexertion/anaerobic conditions (severe pain, anemia, stroke and damage to tissue and organs) Change in shape of RBC Testing NCAA Policy: The Ryan Clark Rule Those who test positive can still participate in athletics Cost: $5-10, paid for by the University Confirmation test ($35) is performed 2nd positive test => education on ways to avoid complications Results of test will be kept confidential to all Exception: Those involved in providing athlete with care during competition, practice and conditioning (Ex. Team doctors, Athletic trainer, etc.) The Genetic Code: mRNA amino acid 9 Translate the sequence 10 Mutations affect phenotypes. How? 11 Point Mutations 12...
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This note was uploaded on 02/27/2012 for the course BIO 0150 taught by Professor Roberts during the Fall '09 term at Pittsburgh.

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Lecture 5 - position 6 in the gene encoding the - subunit...

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