peripheral self tolerance

peripheral self tolerance - MICR3170 Peripheral Self...

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MICR3170 Peripheral Self Tolerance Tolerance- specific unresponsiveness to an antigen due to exposure to that antigen. Natural tolerance- unresponsiveness to self antigen. Acquired tolerance- unresponsiveness to foreign antigen. Tolerance is vital to study due to the role played in Auto immunity, cancer, transplantation, infection and vaccines. There are many factors and conditions that affect tolerance for example a subcutaneous or intramuscular injection of vaccine will have less tolerance that oral or intravenous injection. There are many mechanisms of tolerance. Central tolerance- negative selection of immature lymphocytes by the clonal deletion of self reactive clones during T and B cell development in the thymus and bone marrow respectively. Clonal deletion occurs by the induction of the cell into an apoptotic state. The most important factor of selection is the strength of the signal. Signal strength is dependent four factors; Avidity between antigen and receptor (multiple antigen) Affinity between antigen and receptor (specific antigen) Co stimulatory signals (CD28) Signals to attenuate signal strength (CD5) The importance of central tolerance is demonstrated auto immune disease when the expression of AIRE (autoimmune regulator) Transcription Factor, becomes altered. AIRE causes the transcription of organ specific
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This note was uploaded on 02/25/2012 for the course CJ 3323 taught by Professor Mijares during the Fall '10 term at Texas State.

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peripheral self tolerance - MICR3170 Peripheral Self...

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