Organic Chemistry and Drug Development

Organic Chemistry and Drug Development - Organic Chemistry...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Organic Chemistry & Drug Development The purpose of this lab was to synthesize a library of nine compounds and then use combinatorial chemistry to determine which compound(s) were effective antibiotics against E. coli proliferation. As a result, in this experiment, the starting materials were three A molecules (A1, A2, A3) and three B molecules (B1, B2, B3). The structures of the molecules indicate that all the A molecules were aldehydes with an R group that has an electron withdrawing -NO 2 group on a ring. The ring structures in A1 and A2 were benzene while furan for A2. The carbonyl carbons are good electrophilic sites. The B molecules were hydrazines that had good nucleophilic nitrogen atoms. A reaction between an A molecule and B molecule formed a hydrazone. In regards to reaction, two A molecules or B molecules will not react because the nucleophilic nitrogen atom in B molecules attacks the good electrophilic site of the partial positively charged carbonyl carbon in A molecules. Relying on combinatorial chemistry with mixtures of compounds is extremely useful. This
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/25/2012 for the course CHEM 4385 taught by Professor Staff during the Fall '11 term at Texas State.

Page1 / 2

Organic Chemistry and Drug Development - Organic Chemistry...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online