CPZ - SonjaJoce 1 Absorption:,.Iftakenorally,most ....

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Basic Molecular Pharmacology Coursework Assignment Sonja Joce 1) Absorption:  CPZ is administered via the mouth, the rectum or deep im injection. If taken orally, most  absorption takes place in the small intestine. CPZ is taken up passively dependant on its ionisation and  lipid solubility. The absorption from the GI tract is affected by the presence of food in the stomach which  slows uptake, the formulation of CPZ and gut secretions and enzymes attacking CPZ before it is  absorbed. The bioavailability of CPZ is 30% meaning that 30% of the original dose reaches the systemic  circulation. Rectal administration avoids the GI tract allowing absorption into the systemic circulation. IM  absorption is faster but rate varies dependant on the muscle group it is injected into due to blood flow  difference. Factors that can slow absorption are removal of drug by local blood flow and time taken to  diffuse through the tissue.  Distribution:   This is dependant on blood flow and permeability factors. Blood flow varies in different tissue  groups. In muscles (IM injection) blood flow is slow whereas it is much faster in blood cells, liver, kidney etc.  Volume of distribution is 1470 litres. This exceeds the 40 litres of total body water showing CPZ is stored in  tissue. The plasma protein binding is 97%. This shows most of the drug is  localised  in the plasma and has 
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