Major depressive disorder Medications The use of medications in the treatment of depression began in the late 1950s with the successful introduction of tricyclic antidepressants and MAO inhibitors. Treatment of depression with medications has greatly increased since the advent of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac) and sertraline (Zoloft). While these medications are no more effective than their predecessors, they have fewer side effects and are much safer for patients who may be likely to overdose. Selecting the optimal antidepressant medication is not always a straightforward process, however, and the patient may have to try out various drugs for a period of weeks or months before finding one that is effective for him or her. In addition, while the SSRIs have comparatively few side effects, such complaints as loss of sexual interest or functioning, nervousness, headaches, gastrointestinal complaints, drowsiness, and insomnia can be significant obstacles to the patient's taking the medication as directed. Other mainstream approaches
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Selective serotonin reuptake inhibitor, Major depressive disorder, serotonin reuptake inhibitors, American Psychiatric Association