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lecture 5 (8) - Medication-induced movement disorders...

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Medication-induced movement disorders Treatments In an attempt to prevent acute dystonia from developing, physicians may prescribe a preventative medication along with the antipsychotic (see "Prevention," below). Once neuroleptic-induced acute dystonia has appeared, however, there are several treatment options. A medication called benztropine in doses ranging from 1 mg to 8 mg is effective in reducing symptoms associated with dystonia. Most patients take 2 mg twice daily for seven days for prevention of dystonia at the time they are starting neuroleptic treatment. When benztropine therapy is initiated, the dose is slowly increased. Moreover, when discontinuing the treatment with benztropine, the dose should be slowly decreased to prevent the nausea and vomiting associated with abrupt withdrawal. Another medication that may be useful in treating neurolepticinduced acute dystonia is called trihexyphenidyl . The doses can vary from 10 mg to 45 mg daily. Younger patients may respond better to the treatment with trihexyphenidyl because they can tolerate higher doses. The third pharmacological option is diphenhydramine (Benadryl). This medication can be taken for the period dystonic symptoms last. Another option may include switching the patient to one of the
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