Immune Part 2 March 24(1)

Immune Part 2 March 24(1) - BISC 220 General Biology Cell...

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BISC 220 General Biology Cell Biology and Physiology Instructor for Part 2 Michael Jakowec, PhD [email protected] Lab: MCA-241 (HSC Campus) Office Hours: ? Q & A: Hedco 100 Thursday 2 to 3 pm
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Date Day Lecture No. Topic Mar 3 Thurs 16 Cardiovascular System 1: Heart Mar 8 Tues 17 Cardiovascular System 2: Blood System Mar 10 Thurs 18 Respiratory System Mar 11 Friday Exam Lectures 9 to 16 Mar 15 and 17 Optional Spring Break (Studying of course) Mar 22 Tues 19 Immunity 1 Mar 24 Thurs 20 Immunity 2 Mar 29 Tues 21 Fluid and electrolytic balance 1 Mar 31 Thurs 22 Fluid and electrolytic balance 2 Apr 5 Tues 23 Endocrine System 1 Apr 7 Thurs 24 Endocrine System 2 Apr 8 Friday Exam Lectures 17-23 Apr 12 Tues 25 Reproduction 1 Apr14 Thurs 26 Reproduction 2 Apr 19 Tues 27 Nervous System 1 Apr 21 Thurs 28 Nervous System 2 Apr 26 Tues 29 Motor System 1 Apr 28 Thurs 30 Motor System 2 May 10 Exam Lectures 24 -30
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Lecture 20 Tuesday March 24 Immune System Part 2 Sections 43.3 to 43.4
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Cinematic Study Guides
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Fig. 43-2 INNATE IMMUNITY Recognition of traits shared by broad ranges of pathogens, using a small set of receptors •Rapid response • Recognition of traits specific to particular pathogens, using a vast array of receptors •Slower response ACQUIRED IMMUNITY Pathogens (microorganisms and viruses) Barrier defenses: Skin Mucous membranes Secretions Internal defenses: Phagocytic cells Antimicrobial proteins Inflammatory response Natural killer cells Humoral response: Antibodies defend against infection in body fluids. Cell-mediated response: Cytotoxic lymphocytes defend against infection in body cells.
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Fig. 43-7 Adenoid Tonsil Lymph nodes Spleen Peyer’s patches (small intestine) Appendix Lymphatic vessels Lymph node Masses of defensive cells Blood capillary Lymphatic vessel Tissue cells Interstitial fluid
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Fig. 43-9 Antigen- binding site Antigen- binding site Antigen- binding site Disulfide bridge Variable regions Constant regions Transmembrane region Plasma membrane Light chain Heavy chains T cell  chain  chain Disulfide bridge Cytoplasm of T cell (b) T cell receptor Cytoplasm of B cell a) B cell receptor B cell V V C C V V C C C C V V
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Fig. 43-10 Antigen-binding sites Antigen- binding sites Epitopes (antigenic determinants) Antigen Antibody B Antibody C Antibody A C C C V V V V C
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Fig. 43-11 Antigen Top view: binding surface exposed to antigen receptors Plasma membrane of infected cell Antigen Class I MHC molecule
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Fig. 43-12 nfected cell Antigen ragment Class I MHC molecule T cell eceptor (a) Antigen associates with MHC molecule T cell recognizes combination Cytotoxic T cell (b) Helper T cell T cell receptor Class II MHC molecule Antigen fragment Antigen- presenting cell Microbe 1 1 1 2 2 2 Dendritic Cell Macrophage
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Fig. 43-13 DNA of undifferentiated B cell 1 DNA of differentiated B cell pre-mRNA mRNA Light-chain polypeptide Variable region Constant region Translation B cell B cell receptor RNA processing Transcription DNA deleted between randomly selected V and J segments Functional gene V 37 V 38 V 39 V 40 J 1 J 2 J 3 J 4 C J 5 Intron V 37 V 38 V 39 C J 5
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