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Lecture 19 Immuno 1

Lecture 19 Immuno 1 - BISC 220 General Biology Cell Biology...

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BISC 220 General Biology Cell Biology and Physiology Instructor for Part 2 Michael Jakowec, PhD [email protected] Lab: MCA-241 (HSC Campus) Office Hours: ? Q & A: Hedco 100 Thursday 2 to 3 pm
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Date Day Lecture No. Topic Mar 3 Thurs 16 Cardiovascular System 1: Heart Mar 8 Tues 17 Cardiovascular System 2: Blood System Mar 10 Thurs 18 Respiratory System Mar 11 Friday Exam Lectures 9 to 16 Mar 15 and 17 Optional Spring Break (Studying of course) Mar 22 Tues 19 Immunity 1 Mar 24 Thurs 20 Immunity 2 Mar 29 Tues 21 Fluid and electrolytic balance 1 Mar 31 Thurs 22 Fluid and electrolytic balance 2 Apr 5 Tues 23 Endocrine System 1 Apr 7 Thurs 24 Endocrine System 2 Apr 8 Friday Exam Lectures 17-23 Apr 12 Tues 25 Reproduction 1 Apr14 Thurs 26 Reproduction 2 Apr 19 Tues 27 Nervous System 1 Apr 21 Thurs 28 Nervous System 2 Apr 26 Tues 29 Motor System 1 Apr 28 Thurs 30 Motor System 2 May 10 Exam Lectures 24 -30
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Lecture 19 Tuesday March 22 Immune System Part 1 Sections 43.1 to 43.2
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Cinematic Study Guide
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Why have an immune system?
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The Great Plague of Athens Thucydides (460 – 390 BC) The father of "scientific history", because of his strict standards of evidence-gathering and analysis in terms of cause and effect without reference to intervention by the gods
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Fig. 43-2 INNATE IMMUNITY Recognition of traits shared by broad ranges of pathogens, using a small set of receptors •Rapid response • Recognition of traits specific to particular pathogens, using a vast array of receptors •Slower response ACQUIRED IMMUNITY Pathogens (microorganisms and viruses) Barrier defenses: Skin Mucous membranes Secretions Internal defenses: Phagocytic cells Antimicrobial proteins Inflammatory response Natural killer cells Humoral response: Antibodies defend against infection in body fluids. Cell-mediated response: Cytotoxic lymphocytes defend against infection in body cells.
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Innate Adaptive/Acquired Specificity Structures shared on microbes Microbial antigens, viral antigens, self antigens? Diversity Limited Very large Memory None Yes Self-recognition No Yes (associated with MHC) Blood proteins Complement, cytokines, chemokines Antibodies, cytokines, chemokines Cells macrophages, monocytes, neutrophils, natural killer cells, mast cells, microglia Lymphocytes (T cells, B cells), dendritic cells, macrophages Response Kinetics Rapid (0-3 days) Late (3-7 days) Types of Immunity
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The Complexity of the Immune System
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Fig. 43-4 Induction of Innate Immunity in Insects
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Fig. 43-5
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