DefClass - Definitions and Classifications in Neoplasia...

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Unformatted text preview: Definitions and Classifications in Neoplasia Folder: DefClass (No TP) Updated: February 2, 2011 DefTitle Definitions in Oncology. (Part 1) Neoplasia: Abnormal new cell proliferation of altered cells Heritably Altered Relative autonomous growth Can be benign or malignant (See later) Hyperplasia: Abnormal proliferation of otherwise normal cells Tumor: Solid mass, usually cellular (but not necessarily) Can be neoplastic, non-neoplastic, or even non-cellular "Tumor" usually means a neoplasm in common usage Some free cell neoplasms can be non-tumorous Define1 Definitions in Oncology. (part 2) Metaplasia: Replacement of one type of normal adult differentiated cell type that is normally present, by another normal adult differentiated type that belongs somewhere else. Usually in response to injury or irritation Reversible upon removal of the stimulus Dysplasia Abnormal interaction of cells giving abnormal tissue development Can be pre-neoplastic Define2 Normal Secretory & Ciliated Epithelial Cells Figure 16-19, ECB, 1998, p. 528 RespCilia Ciliated Epithelium of Human Respiratory Tract Progressive Steps in Neoplastic Cell Development: Hyperplasia and Dysplasia Hyper&Dys Progressive Steps in Neoplastic Cell Development: Cancer In situ and Invasive Cancer Situ&Invade Figure 11.7 The Biology of Cancer ( Garland Science 2007) Prpgression in Neoplastic Development: Weinberg, Chapter 11 on Multistep Tumorigenesis. Figure 11.7 Definitions in Oncology. (part 3) Anaplasia: Irreversible loss of normal cell structure and function Positional Anaplasia: Size, shape, arrangement, and overall organization of cells in a tissue are altered Cytological Anaplasia: Intra-cellular structures (mitochondria, cytoskeletal elements, nuclear size and morphology) are altered Cancer: Mass of cells with potentially unlimited growth, serves no useful function for the host, deprives the host of nutrients necessary for survival, expands locally by invasion and systemically by lymphatic and hematogenous pathways, untreated progresses to lethal condition in the host Define3 Benign and Malignant Neoplasia Benign Neoplasm Generally Encapsulated Non-invasive Highly Differentiated Few Mitotic Figures Slow Growth or No Net Growth Little Anaplasia Non-Metastatic (by definition) Malignant Neoplasm...
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DefClass - Definitions and Classifications in Neoplasia...

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