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Unformatted text preview: 12/1/11 1 Prac)cal Bioinforma)cs for Life Scien)sts Week 14, Lecture 28 Istvn Albert Bioinforma)cs Consul)ng Center Penn State Final project A group of researchers are interested in studying protein binding loca)ons in a yet unknown genome. They hypothesize that observed phenotypic varia)ons will correlate with sequence varia)on of the bound loca)ons in this genome. The researchers perform two experimental procedures. 1. First they sequence the whole genome of the wildOtype (normal, wt phenotype with a paired end sequencing technology. 2. Second, they perform a chroma)nOimmunoOprecipita)on experiment that isolates DNA fragments corresponding to bound proteins. This second experiment is performed for both the wildO type ( wt phenotype and the mutant phenotype ( m1) . Final project data (see course webpage 1. The paired end wholeOgenome sequencing is stored in datasets r1.fq and r2.fq 2. ChIPOSeq data for the wildOtype sample is stored in le p1.fq 3. ChIPOSeq data for the mutant sample is stored in3....
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- Fall '11