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1 - 1 Key Concepts for evaluating the patient with an...

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1. Key Concepts for evaluating the patient with an intravascular infection: What is the bug? How did it get there? Where did it come from? Where did it go? 2. Definitions Bacteremia The invasion of the blood stream by pathogenic bacteria. Primary bacteremia Most often a nosocomial infection that is typically associated with an indwelling intravascular catheter, or it is a result of direct inoculation of the blood stream as, for example, a result of intravenous drug use. Secondary bacteremia Occurs when microorganisms causing infection at another site (e.g. pneumonia, pyelonephritis, skin or soft tissue) invade the blood stream and disseminate via the circulation Infective endocarditis (IE) Infection of the endocardial surface of the heart, usually the heart valves. Infection may rarely occur on the chordae tendinae or the atrial or ventricular wall surfaces especially at an area of anatomic abnormality such as septal defects or arteriovenous shunts (such as patent ductus arteriosus). Historically, infective endocarditis has been classified by the
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