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8 - 8 Consequences of the fibrin/platelet/microorganism...

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8. Consequences of the fibrin/platelet/microorganism filled vegetation explain the complications seen clinically with this infection: Persistent bacteremia and risk of seeding distant sites (Where did it go?) resulting in septic arthritis, osteomyelitis, splenic or kidney abscesses, meningeal or brain abscesses, mycotic aneurysms (particularly associated with pyogenic bacteria) that arise from infection of the vasa vasorum of the arterial wall and lead to weakened arterial wall architecture and aneurysm formation. Host response and release of proinflammatory cytokines that provoke the “constitutional symptoms” seen in this infection (fevers, fatigue, anorexia, weight loss, night sweats). Tissue destruction by the microorganism, as in the case for S. aureus through expression of exoenzymes and exotoxins controlled by global regulators such as agr and sar leading to incompetent valvular function and congestive heart failure or atrioventricular conduction abnormalities.
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