Unformatted text preview: Favorite board questions: Chediak Higashi syndrome - Defective neutrophil chemotaxis occurs from inadequate signaling, abnormal receptors for chemo-attractants, or disorders of locomotion. S. aureus most common pathogen. Abnormalities of microbial killing power are typically inherited. Most common is chronic granulomatous disease (CGD). The enzyme NADPH oxidase is deficient and H 2 2 is not formed. Patients are at risk for infection with catalase positive organisms (S. aureus). Organisms that make their own hydrogen peroxide, like pneumococci and streptococci are killed by neutrophils. Myeloperoxidase is present and uses the H 2 2 to make lethal oxygen free radicals....
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- Fall '10
- Anatomy, S. aureus, CGD, subcutaneous connective tissue, Defective neutrophil chemotaxis