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Approach to Opportunistic Infectio1

Approach to Opportunistic Infectio1 - Favorite board...

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Approach to Opportunistic Infection 1. General Introduction Definition: Person suffering from disruption of defenses of specific organ or system or from abnormalities of humoral or cellular immunity. 2. Causes of Immunocompromise and Consequences 2.1. Barrier Breech of the integument leads to infections of skin, and subcutaneous connective tissue. 2.2. Phagocytic function Defects in neutrophil function, either qualitatively or quantitatively are associated with infection. Decreased number of leukocytes associated with severe infections, bacteremia and fever at levels below 500 absolute neutrophils. There are congenital deficiencies of chemotaxis, which result in infection. These are rare.
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Unformatted text preview: Favorite board questions: Chediak Higashi syndrome - Defective neutrophil chemotaxis occurs from inadequate signaling, abnormal receptors for chemo-attractants, or disorders of locomotion. S. aureus most common pathogen. Abnormalities of microbial killing power are typically inherited. Most common is chronic granulomatous disease (CGD). The enzyme NADPH oxidase is deficient and H 2 2 is not formed. Patients are at risk for infection with catalase positive organisms (S. aureus). Organisms that make their own hydrogen peroxide, like pneumococci and streptococci are killed by neutrophils. Myeloperoxidase is present and uses the H 2 2 to make lethal oxygen free radicals....
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