Unformatted text preview: bacterium seen in patients with this defect. Parasite example is Toxoplasma gondii, viruses in Herpes family, fungi like cryptococcus. Primary cell mediated immune deficiency is usually congenital – Dx in childhood and lethal. Acquired defects usually arise in transplantation (solid organ and bone marrow) through use of immunosuppressive drugs, or viral infection (HIV). 2.5. Temporal sequence There is a general temporal sequence following transplantation. 1. Early post transplant – o postoperative complications. ICU type organisms 2. Months 1-4 – o CMV, Candida, Aspergillus. 3. Months 4-12 – o Cryptococcus, Listeria. 3. Principles of Management • Diagnose aggressively • Treat early • More than one pathogen may be present ie. CMV and Aspergillus, CMV and PCP, Nocardia and Aspergillus. • Physical signs may be masked due to absence of neutrophils. • Prevention generally better than waiting to treat....
View Full Document
- Fall '10
- Anatomy, CMV, late component deficiencies, general temporal sequence, ICU type organisms, Early post transplant