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Unformatted text preview: bacterium seen in patients with this defect. Parasite example is Toxoplasma gondii, viruses in Herpes family, fungi like cryptococcus. Primary cell mediated immune deficiency is usually congenital Dx in childhood and lethal. Acquired defects usually arise in transplantation (solid organ and bone marrow) through use of immunosuppressive drugs, or viral infection (HIV). 2.5. Temporal sequence There is a general temporal sequence following transplantation. 1. Early post transplant o postoperative complications. ICU type organisms 2. Months 1-4 o CMV, Candida, Aspergillus. 3. Months 4-12 o Cryptococcus, Listeria. 3. Principles of Management Diagnose aggressively Treat early More than one pathogen may be present ie. CMV and Aspergillus, CMV and PCP, Nocardia and Aspergillus. Physical signs may be masked due to absence of neutrophils. Prevention generally better than waiting to treat....
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- Fall '10