Emerging Infectious Disease4

Emerging Infectious Disease4 - How to distinguish from...

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Emerging Infectious Diseases 9.1.2. Diagnosis culture from blood, although this occurs late in fatal disease process 9.1.3. Management antibiotics, supportive care o Ciprofloxacin o Doxycycline prophylaxis for other possibly exposed individuals o Ciprofloxacin or doxycycline for 60 days o Immunization (3 doses required at 0, 2, and 4 weeks) 9.2. Smallpox (Variola major) A unique DNA virus for which humans are its only reservoir. 9.2.1. Mode of transmission: person to person spread by air droplets/aerosols 9.2.2. Pathogenesis: Inahalation of air droplet mucosal replication and viremia dissemination to organs and skin INCUBATION PHASE (7-17 [12] DAYS) 2 ND viremia TOXEMIC PHASE rash (3-4d), high fevers, myalgias head arms + hands legs and trunk HIGHLY INFECTIOUS VIRAL SHEDDING LESIONS
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Unformatted text preview: How to distinguish from chickenpox: • Smallpox lesions develop at the same pace and are uniform in appearance and deep in skin • Chickenpox lesions are more superficial, develop in crops over several days and are at varying stages from vesicle to scab to crust at any given time • Smallpox lesions are “top heavy” – head, arms, legs, then trunk Chickenpox lesions most dense on the trunk 9.2.3. Treatment: isolation, supportive care 9.2.4. Prevention: vaccination before exposure or within 2 to 3 days of exposure Vaccinia live virus • Complications: o Accidental infection o Generalized vaccinia o Eczema vaccinatum o Postvaccinal encephalopathy o Progressive vaccinia o Myocarditis...
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Emerging Infectious Disease4 - How to distinguish from...

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