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Unformatted text preview: 12.1. Key Concepts: • Novel strains of MRSA infecting healthy children and adults • Strains differ from major clones of hospital acquired (HA) MRSA by: o Composition of gene cassette coding for resistance CA-MRSA strains often only resistant to ß-lactams and usually remain susceptible to s, clindamycin, and trimethroprim-sulfamethoxazole o Carriage of plasmids encoding resistance o Virulence factors (Panton-Valentine leukocidin (PVL) toxin) Likely accounts for major syndrome of skin and soft tissue infections associated with these strains • As clinician, MUST consider Methicillin Resistance even in the healthy adult with implications for appropriate choice of empiric antibiotics. 13. Evolution of Resistance Genes Vancomycin (Glycopeptide) Intermediate Staphylococcus aureus (VISA)...
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This note was uploaded on 03/02/2012 for the course BSC BSC1086 taught by Professor Joystewart during the Fall '10 term at Broward College.
- Fall '10