GI Diarrhea and Others4. An overview of therapyThe most devastating consequences of acute infectious diarrhea relate to fluid losses. Toxigenic organisms, such as V. cholerae andETEC, can cause severe dehydration. The major aim of treatment is replacement of fluid and electrolytes. The traditional route of administration has been intravenous, but in recent years oral rehydration therapy (ORT) has proven equally effective physiologically and more practical logistically, especially in developing countries. Indeed, ORT is the treatment of choice for mild to moderate diarrhea in both children and adults, and it can be used even in severe diarrhea after some initial parenteral fluid replacement.Less than one-tenth of patients with acute diarrhea can be treated successfully with antimicrobial drugs . Among the types that should be treated with such drugs are shigellosis, cholera, and C. difficile diarrhea. There are conflicting reports concerning the efficacy of antimicrobial drugs in
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