Tuberculosi2 - Tuberculosis Recrudescence usually occurs at...

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Tuberculosis Recrudescence usually occurs at sites seeded during the silent bacillemia, especially the apex of the lung.The most common presentation of TB is an apical lung infiltrate, often with fibrosis and cavitation. Pathologically, reactivation TB is characterized by caseating necrosis within granulomas. Liquefaction of caseation necrosis forms cavities containing enormous numbers of TB bacilli. In these patients, CMI causes tissue damage to the host, without being robust enough to contain TB infection. The symptoms of TB are mainly caused by cytokine release as a result of CMI, namely, fever, sweats, weight loss, as well as symptoms from local inflammation (cough, hemoptysis, bone pain, etc). Highly immunosuppressed patients may have few symptoms. Moreover, symptoms in immunocompetent patients may be relieved by the administration of drugs that suppress CMI, such as corticosteroids. The diagnosis of TB should be suspected on the basis of typical symptoms (prolonged cough,
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This note was uploaded on 03/02/2012 for the course BSC BSC1086 taught by Professor Joystewart during the Fall '10 term at Broward College.

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