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Study Guide First Half Midterm

Study Guide First Half Midterm - TERMS AND DEFINITIONS 1...

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TERMS AND DEFINITIONS 1. Active Invasion – Presence of proteases, and presence of motile cells. 2. Adenocarcinoma – Sac-like (glandular neoplasm) growth of malignant epithelial tissue. Tumor derived from secretory epithelial cells. 3. Age-adjusted Cancer death rates per 100,000:1990 to the present – Rates are decreasing with time. 4. Aflatoxin – Carcinogenic product produced by molds. 5. Anaplastic Cell – Structurally abnormal. (Referring to a tumor) having a tissue and cellular architecture lacking the differentiated characteristics of the tissue of origin. 6. Aneuploidy – Abnormal number and form of chromosomes. Describing a karyotype that deviates from diploid because of increases or decreases in the numbers of certain chromosomes. Can be part of late-stage pathogenesis in cancer as well. 7. Angiogenesis – Tumor implant into chicken chorioallantoic membrane can be used to study angiogenesis. Process by which new blood vessels are formed. Also called neoangiogenesis. Vascularization. 8. Animal Leukemia Models – Used to develop chemotherapeutic agents to cure childhood ALL. 9. Anoxia – A state or environment in which oxygen is essentially absent. 10. APC – (Antigen-presenting cells) Used in early colon cancer detection. 11. Athymic Mice – Accepts xenogeneic cancers. 12. B16F10 Melanoma – A model used to study cancer metastasis. 13. Benign Neoplasia – Generally encapsulated 14. Breast Cancer – No natural born babies, older age at first birth increases the risk of breast cancer. It is the leading site of cancer incidence in women. The onset of menstruation late in a girl’s development decreases the risk of breast cancer. 15. Brian Cancer Scan – Shows growth rate of a clinical human cancer. 16. Cachexia – Progressive wasting in cancer patients. Effect of tumor necrosis factor. Can be part of late-stage pathogenesis in cancer. 17. Carcinogen – An agent that contributes to the formation of a tumor. 18. Carcinoma – Cancer arising from epithelial cells. 19. Carcinoma in situ – Localized early stage cancer of epithelial origin.
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20. CD20 Markers – Target for Bexxar in “Liquid Radiation”. An antigen that is displayed on the surface of many cell types of the B-Cell lineage. 21. Cell Surface Adhesion Molecule 20 – Can explain target tissue-specific seeding by metastatic cells. 22. Cloning Efficiency of 51% - Seed 1,000 cells in culture, get 510 colonies. 23. Cytoskeleton – Network of proteins in the cell, largely in the cytoplasm, that provides it with structure and rigidity and enables it to exhibit motile behavior. 24. Cytoskeletal Abnormalities – May facilitate cell deformability.May underlie the loss of density-dependent inhibition of mitosis in neoplastic cells. 25.
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Study Guide First Half Midterm - TERMS AND DEFINITIONS 1...

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