Models - Model Systems in Cancer Biology and Cancer...

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Unformatted text preview: Model Systems in Cancer Biology and Cancer Medicine Updated: February 14, 2011 Folder Title: Models ModlTitl Studying the Basic Biology of "Cancer" Generalizations About "Cancer" Model Systems and Research Objectives • Cell Biology and Cancer Genetic Structure Progression Biochemistry Cell Cycle Regulation • Growth Control • Immunology and Cancer • Virology and Cancer • Cancer Chemotherapy BioModel Cancer Model Systems In Vitro (in Cell, Tissue, or Organ Culture) Normal Cells in Culture • Transformed Cells Chemically Virally By Irradiation • Neoplastic Cells from Animal Tumors • Neoplastic Cells Cultured from Human Cancers CxVitro Animal Tumor Models in Vivo Source of the Tumor Challenge Cells • Implanted Cultured Neoplastic Cells • Transplanted from Donor Animals Early vs Later Transplant Generations • Induced in the Tumor-bearing Host Animals Spontaneous (by Genetic Selection) Chemical, Viral, Radiation Induction • Excised fromVeterinaryAnimals AnimlCx1 Tumor Models (Animal and Plant) in Vivo Host Specie s Mice (Inbred Strains) Rats, Hamsters, Guinea Pigs Rabbits Cancers in Veterinary Animals Cancers in the Wild Animals Plants AnimlCx2 Animal Tumor Models in Vivo Routes of Challenge • IP (Intraperitoneal) • SC (Sub-cutaneous) • IM (Intra-Muscular) • ID (Intra-dermal) • IV (Intravenous) • IT (Intra-thecal) • PO (Orally) AnimlCx3 Animal Models in Cancer Chemotherapy Mammalian Models: • Mice and Rats • Hamsters • Guinea Pigs Strengths • Genetic and Physiological Relationship to Humans • Immune Response Similarities to Human Responses • Rapid Gestation • Small Body Size • Inbred Genetically Identical and Congenic Strains...
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This note was uploaded on 03/03/2012 for the course BIO 501 taught by Professor Thomasfondy during the Spring '11 term at Syracuse.

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Models - Model Systems in Cancer Biology and Cancer...

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