hetero - Tumor Cell Heterogeneity Updated: February 24,...

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Unformatted text preview: Tumor Cell Heterogeneity Updated: February 24, 2010 Folder Title: Hetero HetTitle See Chapter 13 in Weinbergs Biology of Cancer: pp. 527 to 556, Heterotypic Interactions Selected Molecular and Phenotypic Characteristics of Cancer Cells: Ideas for Therapy Embryonic, Undifferentiated Induce differentiation Large Nucleus, Excess DNA DNA-directed Anticancer Agents & XRay Defects in DNA Repair DNA-directed Anticancer Agents & Xray Secrete Proteases for Invasion Protease Inhibitors Aberrant Mitoses Mitotic Poisons Rapid Cell Division Anti-proliferative agents Anchorage-independent growth Cytoskeletal-directed agents: Microtubule and cytoskeletal anomalies and microfilament-directed Failure to senesce (to exhibit ageing) Inhibit telomerase Failure to invoke Apoptosis Activate Cell-death programs Invasive Inhibit proteolytic activity, inflammatory activity and motility Metastatic Inhibit seeding at distant sites Induces host cell support Inhibit angiogenesis and other host responses supporting tumor growth R T K R T K Ras Pathway S H C GDP GTP CD-GEGII GAP GTP Elk1 c-Fos ATF2 c-Jun A c t i n C y t o s k e l e t o n P P P P P P Stress Fibers and Focal Adhesions Gene Expression PLD Pathway PLD Pathway PMA Growth Factors Increased T Cell Adhesion In te g rin s 1 2 2 1 1 SOS p120- GAP p190-B Rho PI3K PLC- Rap1A PLD RalBP1 PAKs ERKs ERKs JNKK JNK JNK MEKK1 CDC42 Rac MEKs Raf RalGDS Ral GRB2 T C R A ntigen Lck GEF Ras Ras 2009 ProteinLounge.com C (Please send in your name under Send User Data)...
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This note was uploaded on 03/03/2012 for the course BIO 501 taught by Professor Thomasfondy during the Spring '11 term at Syracuse.

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hetero - Tumor Cell Heterogeneity Updated: February 24,...

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