chapter15 SHORT RKW-1

chapter15 SHORT RKW-1 - Lecture Connections 15 | Principles...

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Lecture Connections 15 | Principles of Metabolic Regulation © 2009 W. H. Freeman and Company
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Homeostasis Organisms maintain homeostasis by keeping the concentrations of most metabolites at steady state In steady state, the rate of synthesis of a metabolite equals the rate of breakdown of this metabolite
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Active Protein Molecules have a Finite Lifespan Different proteins in the same tissue have very different half-lives less than an hour to about a week for liver enzymes The stability correlates with the sequence at N- terminus Some proteins are as old as you are Crystallins in the eye lens
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Phosphorylation of Enzymes Affects their Activity Protein phosphorylation is catalyzed by protein kinases Dephosphorylation is spontaneous, or catalyzed by protein phosphatases Typically, hydroxyl groups of Ser, Thr, or Tyr are phosphorylated
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Some Enzymes in the Pathway Limit the Flux of Metabolites More than Others Hexokinase and phosphofructokinase are appropriate targets for regulation of glycolytic flux
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This note was uploaded on 03/08/2012 for the course CHEM 481 taught by Professor Wood during the Fall '10 term at BYU.

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chapter15 SHORT RKW-1 - Lecture Connections 15 | Principles...

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