chapter17 RKW

chapter17 RKW - Lecture Connections 17 | Fatty Acid...

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Unformatted text preview: Lecture Connections 17 | Fatty Acid Catabolism © 2009 W. H. Freeman and Company Why do we care about fats? • Weight loss. • one third of our overall energy • 80% of energy for heart and liver • hibernating animals, rely on fats Fats Provide Efficient Fuel Storage • The advantage of fats over polysaccharides: – Fatty acid carry more energy per carbon because they are more reduced – Fatty acids carry less water along because they are nonpolar • Glucose and glycogen are for short-term energy needs , quick delivery • Fats are for long term (months) energy needs , good storage, slow delivery Fat Digestion • Catabolic process • Major principle: – Catabolism will converge on a common intermediate. – We can use enzymes already used in ther processes. Chylomicron Hormones Trigger Mobilization of Stored Triacylglycerols • When the fatty acids are stored in adipocytes how do we access the energy? Hydrolysis of Fats Yields Fatty Acids and Glycerol • hydrolysis of triacylglycerols is catalyzed by lipases • some lipases are regulated by hormones glucagon and epinephrine • epinephrine means: “ we need energy now ” • glucagon means: “ we are out of glucose ” Hormones: Epinephrine Glucagon Perilipin – protien That coats lipids to Immobilize them. Perilipin phosphorylation Allows hormone sensitive lipase to bind Hormone sensitive lipase Hydrolizes triacylglycerol To fatty acids and glycerol Triacyl glycerol activation • Fatty acids to bloodstream – to cells • How do we use the glycerol? – Is it similar to any molecules we have used previously? Glycerol from Fats Enters Glycolysis • Glycerol kinase activates glycerol at the expense of ATP • Subsequent reactions recover more than enough ATP to cover this cost • Allows limited anaerobic catabolism of fats Into second Half of Glycolysis NADH and 2 more ATP Invest ATP to Activate 2.5 ATP/NADH Fatty Acids are Converted into...
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chapter17 RKW - Lecture Connections 17 | Fatty Acid...

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