Lecture 6 - Respiratory

Lecture 6 - Respiratory - Lecture 6: Organization of the...

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Lecture 6: Organization of the Mammalian Respiratory System Introduction o “For millennia, people have regarded breathing as being synonymous with life. Life begins and ends with breathing. God breathed into [Adam’s] nostrils the breath of life and then later used part of Adam’s ventilatory apparatus (a rib) to give life to Eve” o Life begins and ends with breathing—very true! Merrill personally observed birth of his children except for his first son. Similarities between life and death: Birth o new born comes out very cyanonic????? ---meaning the hue of the skin of the face isn’t the everyday skin color, but it’s a purple grey, ashy death look; first thing that you see o next few seconds, as the thoracic cavity emerges, the thorax and limbs look like the same color as the face—hue of grey and purple cyanosis o long time ago, doctor would smack baby’s back to make it breathe and respiration begins—ashy grey color changes to pink, tan color o God breathed into [Adam’s] nostrils the breath of life and then later used part of Adam’s ventilatory apparatus (a rib) to give life to Eve” there has been a lot of lost in translation example: God didn’t literally breathe into Adam like CPR doesn’t believe that a rib was extracted from Adam’s side to create a woman but these statements are not far from what actually did happen Diffusion of Respiratory gases in uni- vs multicellular organisms o picture illustrates living organisms in terms of how they exchange gases and how bulk air/bulk fluids vs diffusion of a substance based on concentration gradients or pressure gradients occurs o Slope of O2 the steeper the slope of the O2, the more rapid the exchange the slope are mainly the alveoli and mitochondria in order for gas to get into the alveolus, oxygen must come from outside and CO2 must come from tissue spaces, following release by the mitochondria o Mammalian system (D): air pump system that delivers inspired air by convection circulatory system with pump the delivers gas suspended in liquid by convection Slide 1
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only important diffusion for gas delivery: is across cell membranes, through cytoplasm, through interstitial space, and w/in blood vessel, in respiratory tubules (bronchioles, etc) o exchange of gases: higher concentration (partial pressure) lower concentration (partial pressure) o exchange based on diffusion is by-directional : the net exchange is in direction of large arrow but diffusion occurs the other way too! Respiratory Gas Laws o Boyle’s Law: volume = pressure pressure = volume o Dalton’s Law P z = X z * P total P z = single gas pressure (partial pressure) X z = mole fraction (fractional composition) P total = total pressure of mixture of gases Look at right side!
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Lecture 6 - Respiratory - Lecture 6: Organization of the...

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