7101 - Vitamin D and risk of Type 1 diabetes Dr Elina...

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Unformatted text preview: Vitamin D and risk of Type 1 diabetes Dr Elina Hyppnen MSc, MSc, MPH, PhD Centre for Pediatric Epidemiology and Biostatistics Institute of Child Health London, UK email: e.hypponen@ich.ucl.ac.uk Overview Health effects of Vitamin D Type 1 diabetes Vitamin D and type 1 diabetes Public health importance Health effects of vitamin D Traditionally: regulation of calcium homeostasis and bone metabolism More recently suggested to affect a wide-range of diseases, including autoimmune disorders, cancer, metabolic syndrome Vitamin D is known to modulate immune function in humans suppresses (overaggressive) reactions Etiology of type 1 diabetes Destruction of beta cells by autoimmune process Length of latency period varies, often very long Disease develops in a genetically susceptible individual after (series of) environmental insults Viral infections and several dietary factors suggested to be involved in the pathogenic process Vitamin D & Type 1 diabetes- Seasonal and geographical variation Some evidence for north-south gradient exceptions (e.g. Sardinia)exceptions (e....
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This note was uploaded on 03/08/2012 for the course PHARM 300 taught by Professor Staff during the Fall '11 term at Rutgers.

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7101 - Vitamin D and risk of Type 1 diabetes Dr Elina...

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